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FEBS Lett 376:8186 Rennenberg H (1980) Glutathione metabolism and possible biological roles in higher plants

the lactate dyscrasia theory) proposes that mitochondrial dysfunction partly contributes to an accumulation of lactate in the junction of motor neurons and muscle cells (the neuromuscular junction (NMJ)) leading to death of both the nerve and muscle cells, thereby requiring the remaining muscle cells to work harder-than-normal to generate the force necessary for motor control

This not only causes great difficulties for patients to take care of themselves in daily life but also brings a heavy burden to families and society (O'shea et al., 2017)

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